Every Patient Is Unique

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Every Patient Is Unique

Gain insight to provide optimal care

Patients’ response to medications is not uniform. Not every drug works for every patient. Individual patients may respond differently to the same drug in terms of:

  • Efficacy
  • Side effects
  • Toxicity
Patient holding hands

Variation in drug response is due in part to genetic factors.

At RPRD, we offer pharmacogenomics (PGx) solutions to optimize medication selection and dosage for individual patients based on their unique genetic composition.

Preemptive PGx

We are a pioneer in preemptive PGx. Our comprehensive PGx solutions have the potential to help clinicians and healthcare organizations:

  • Reduce ADRs; resulting in fewer ER visits and lower mortality rates
  • Reduce length of stay (LOS)
  • Lower readmission rate
  • Reduce total cost per discharge
  • Improve patient’s drug adherence
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Institute Whole Pharmacogenomics Scan (WPS)

Interrogate a whole range of PGx variants in an individual patient and preemptively retrieve comprehensive PGx information for later use

Allow patient’s PGx profile to be available before clinical decisions are made regarding future medications

Embrace potentially life-saving clinical decisions regarding best treatment options

Case example

A leading U.S. pediatric hospital:

  • Utilizing preemptive PGx for patient care using WPS and its predecessor since 20116,7
  • Nearly 4,500 patients have benefited from the program as of November 20188

Additional Resources:

Read more on the value of preemptive PGx and how to overcome the challenges to integrate PGx into patient care:

Preemptive pharmacogenomics-working towards bringing timely, individually tailored, precision health care to patients

Benefit of Preemptive Pharmacogenetic Information on Clinical Outcome

References
  1. Spear BB, et al. Clinical Application of Pharmacogenetics. Trends Mol. Med. 2001 May;7(5):201-4.
  2. FDA “Preventable Adverse Drug Reactions.” 2018.
  3. Relling MV, et al. Pharmacogenomics in the Clinic. Nature. 2015 Oct;526(7573):343-50.
  4. Ji Y, et al. Preemptive Pharmacogenomic Testing for Precision Medicine: A Comprehensive Analysis of Five Actionable Pharmacogenomic Genes Using Next-Generation DNA Sequencing and a Customized CYP2D6 Genotyping Cascade. J Mol. Diagn. 2016 May;18(3):438-46.
  5. Dunnenberger HM, et al. Preemptive Clinical Pharmacogenetics Implementation: Current Programs in Five US Medical Centers. Annu Rev Pharmacol Toxicol. 2015 Jan;55:89-106.
  6. Hoffman JM, et al. PG4KDS: a Model for the Clinical Implementation of Pre-emptive Pharmacogenetics. Am J Med Genet C Semin Med Genet. 2014 Mar;166C(1):45-55.
  7. https://www.prnewswire.com/news-releases/rprd-diagnostics-partners-with-st-jude-childrens-research-hospital-to-offer-comprehensive-pharmacogenetics-testing-300539615.html
  8. PG4KDS: Clinical Implementation of Pharmacogenetics.

 

Additional case example resource: https://www.stjude.org/research/clinical-trials/pg4kds-pharmaceutical-science/implementation-resources-for-professionals.html

Evidence-based care

Elevate standard of care using our PGx testing results and recommendations based on clinical evidence curated by RPRD experts, from CPIC guidelines, FDA label information, and other peer-reviewed scientific studies.

Testing Menu

At RPRD, we offer a range of PGx testing services including targeted PGx panels, comprehensive Whole Pharmacogenomics Scan (WPS), and tailored solutions using genotyping platforms or NGS.